Charly Coughran wrote:
> convicted neighbor Alan S <loralgtweightandcarbs@[EMAIL PROTECTED]
> wrote:
>
http://groups.google.com/group/sci.med.cardiology/msg/8d385732b737675e?
>
> > I'm going back through various subscriptions I have to
> > different medical re****ts servers.
> >
> > Please excuse me if any of the re****ts I post have been
> > discussed while I was away.
> >
> > A discussion on this one appeared in Endocrine Today
> > http://www.endocrinetoday.com/view.aspx?rid=26757
> >
> > "Relation between fasting glucose and retinopathy for
> > diagnosis of diabetes: three population-based
> > cross-sectional studies."
> >
> > http://tinyurl.com/3g8oo5
> >
> > Full version (pay)
> >
http://www.thelancet.com/journals/lancet/article/PIIS0140673608603189/fulltext
> >
> > The im****tant bits:
> >
> > "However, we found inconsistent evidence of a uniform
> > glycaemic threshold for prevalent and incident retinopathy,
> > with analyses suggesting a continuous relation. The widely
> > used diabetes FPG cutoff of 7.0 mmol/L or higher had
> > sensitivity less than 40% (range 14.8-39.1) for detecting
> > retinopathy, with specificity between 80.8% and 95.8%."
> > and
> > "The current FPG cutoff of 7.0 mmol/L used to diagnose
> > diabetes did not accurately identify people with and without
> > retinopathy. These findings suggest that the criteria for
> > diagnosing diabetes could need re*****sment."
> >
> > 7 mmol/l is 126mg/dl.
> >
> > The abstract:
> >
> > Centre for Eye Research Australia, University of Melbourne,
> > VIC, Australia. twong@[EMAIL PROTECTED]
> >
> > BACKGROUND: The WHO and American Diabetes Association
> > criteria for diagnosing diabetes mellitus assume the
> > presence of a glycaemic threshold with high sensitivity for
> > identifying retinopathy. However, this assumption is based
> > on data from three previous studies that had im****tant
> > limitations in detecting retinopathy. We aimed to provide
> > updated data for the relation between fasting plasma glucose
> > (FPG) and retinopathy, and to *****s the diagnostic accuracy
> > of current FPG thresholds in identifying both prevalent and
> > incident retinopathy. METHODS: We examined the data from
> > three cross-sectional adult populations: those in the Blue
> > Mountains Eye Study (BMES, Australia, n=3162), the
> > Australian Diabetes, Obesity and Lifestyle Study (AusDiab,
> > Australia, n=2182), and the Multi-Ethnic Study of
> > Atherosclerosis (MESA, USA, n=6079). Retinopathy was
> > diagnosed from multiple retinal photographs of each eye, and
> > graded according to the modified Airlie House Classification
> > system. Plasma glucose concentrations were measured from
> > fasting venous blood samples. FINDINGS: The overall
> > prevalence of retinopathy was 11.5% in BMES (95% CI
> > 10.4-12.6%), 9.6% in AusDiab (8.4-10.9), and 15.8% in MESA
> > (14.9-16.7). However, we found inconsistent evidence of a
> > uniform glycaemic threshold for prevalent and incident
> > retinopathy, with analyses suggesting a continuous relation.
> > The widely used diabetes FPG cutoff of 7.0 mmol/L or higher
> > had sensitivity less than 40% (range 14.8-39.1) for
> > detecting retinopathy, with specificity between 80.8% and
> > 95.8%. The area under receiver operating characteristic
> > curves for FPG and retinopathy was low and ranged from 0.56
> > to 0.61. INTERPRETATION: We saw no evidence of a clear and
> > consistent glycaemic threshold for the presence or incidence
> > of retinopathy across different populations. The current FPG
> > cutoff of 7.0 mmol/L used to diagnose diabetes did not
> > accurately identify people with and without retinopathy.
> > These findings suggest that the criteria for diagnosing
> > diabetes could need re*****sment.
>
> For some time it has been becoming clearer and clearer that
> prediabetes is, in fact, frank diabetes and the high end of normal is
> probably also diabetes.
Incorrect.
Instead, the correct diagnosis would be metabolic syndrome (MetS).
It is our collective clinical experience that the PIACs from VAT are
the cause of the inflammation-associated conditions such as
retinopathy, neuropathy, myopathy, and vasculopathy for folks with
MetS instead of their hyperglycemia, which can even be absent for
those blessed with a strong pancreas.
Frank type-2 diabetes is simply a more extreme form of MetS.
Be hungry... be healthy... be hungrier... be euglycemic...
Prayerfully in the awesome name of LORD Jesus Christ,
Andrew <><
--
http://groups.google.com/group/sci.med.cardiology/msg/cd9918679e6b3d6f?
|
